Optimising EEG-fMRI for Localisation of Focal Epilepsy in Children.

ABSTRACT:

Background

Early surgical intervention in children with drug resistant epilepsy has benefits but requires using tolerable and minimally invasive tests. EEG-fMRI studies have demonstrated good sensitivity for the localization of epileptic focus but a poor yield although the reasons for this have not been systematically addressed. While adults EEG-fMRI studies are performed in the "resting state"; children are commonly sedated however, this has associated risks and potential confounds. In this study, we assessed the impact of the following factors on the tolerability and results of EEG-fMRI in children: viewing a movie inside the scanner; movement; occurrence of interictal epileptiform discharges (IED); scan duration and design efficiency. This work's motivation is to optimize EEG-fM

SUBMITTER: Centeno M 

PROVIDER: S-EPMC4752259 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature