Layer-by-Layers of Polymeric Micelles as a Biomimetic Drug-Releasing Network.
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ABSTRACT:
SUBMITTER: Authimoolam SP
PROVIDER: S-EPMC4752428 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
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Layer-by-Layers of Polymeric Micelles as a Biomimetic Drug-Releasing Network.
Authimoolam Sundar P SP Lakes Andrew L AL Puleo David A DA Dziubla Thomas D TD
Macromolecular bioscience 20150929 2
Mucin networks are lubricous biofunctional coats formed through the continuous deposition of mucin glycoproteins. Previously, we demonstrated the synthesis of a mucin mimic using biotinylated-filomicelles crosslinked via streptavidin using a layer-by-layer approach. These networks recreate the fibrous nature of mucin and can serve as a drug-releasing network. In this work, the ability to vary the network properties by blending filomicelles with spherical micelles is demonstrated. In addition, th ...[more]
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