Sex Differences in Circadian Dysfunction in the BACHD Mouse Model of Huntington's Disease.

ABSTRACT: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that affects men and women in equal numbers, but some epidemiological studies indicate there may be sex differences in disease progression. One of the early symptoms of HD is disruptions in the circadian timing system, but it is currently unknown whether sex is a factor in these alterations. Since sex differences in HD could provide important insights to understand cellular and molecular mechanism(s) and designing early intervention strategies, we used the bacterial artificial chromosome transgenic mouse model of HD (BACHD) to examine whether sex differences in circadian behavioral rhythms are detectable in an animal model of the disease. Similar to BACHD males, BACHD females display circadian disruptions at both

SUBMITTER: Kuljis DA 

PROVIDER: S-EPMC4752447 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature