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Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).


ABSTRACT: The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype and the understanding of pathophysiological mechanisms in asthma without Type 2 cytokine inflammation is limited. RASP-UK will objectively assess adherence to corticosteroids (CS) and examine a novel composite biomarker strategy to optimise CS dose; this will also address what proportion of patients with severe asthma have persistent symptoms without eosinophilic airways inflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies.

SUBMITTER: Heaney LG 

PROVIDER: S-EPMC4752622 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).

Heaney Liam G LG   Djukanovic Ratko R   Woodcock Ashley A   Walker Samantha S   Matthews John G JG   Pavord Ian D ID   Bradding Peter P   Niven Robert R   Brightling Chris E CE   Chaudhuri Rekha R   Arron Joseph R JR   Choy David F DF   Cowan Douglas D   Mansur Adel A   Menzies-Gow Andrew A   Adcock Ian I   Chung Kian F KF   Corrigan Chris C   Coyle Peter P   Harrison Timothy T   Johnston Sebastian S   Howarth Peter P   Lordan James J   Sabroe Ian I   Bigler Jeannette J   Smith Dirk D   Catley Matthew M   May Richard R   Pierre Lisa L   Stevenson Chris C   Crater Glenn G   Keane Frank F   Costello Richard W RW   Hudson Val V   Supple David D   Hardman Tim T  

Thorax 20150723 2


The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype and the understanding of pathophysiological mechanisms in asthma without Type 2 cytokine inflammation is limited. RASP-UK will objectively assess adherence to corticosteroids (CS) and examine a novel composite bio  ...[more]

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