Ontology highlight
ABSTRACT:
SUBMITTER: Wei PC
PROVIDER: S-EPMC4752721 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Wei Pei-Chi PC Chang Amelia N AN Kao Jennifer J Du Zhou Z Meyers Robin M RM Alt Frederick W FW Schwer Bjoern B
Cell 20160201 4
Repair of DNA double-strand breaks (DSBs) by non-homologous end joining is critical for neural development, and brain cells frequently contain somatic genomic variations that might involve DSB intermediates. We now use an unbiased, high-throughput approach to identify genomic regions harboring recurrent DSBs in primary neural stem/progenitor cells (NSPCs). We identify 27 recurrent DSB clusters (RDCs), and remarkably, all occur within gene bodies. Most of these NSPC RDCs were detected only upon m ...[more]