Ontology highlight
ABSTRACT:
SUBMITTER: Thutkawkorapin J
PROVIDER: S-EPMC4752738 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Thutkawkorapin Jessada J Picelli Simone S Kontham Vinaykumar V Liu Tao T Nilsson Daniel D Lindblom Annika A
BMC genetics 20160213
<h4>Background</h4>Heritable factors are well known to increase the risk of cancer in families. Known susceptibility genes account for a small proportion of all colorectal cancer cases. The aim of this study was to identify the genetic background in a family suggested to segregate a dominant cancer syndrome with a high risk of rectal- and gastric cancer. We performed whole exome sequencing in three family members, 2 with rectal cancer and 1 with gastric cancer and followed it up in additional fa ...[more]