Ontology highlight
ABSTRACT:
SUBMITTER: Zak KM
PROVIDER: S-EPMC4752817 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Zak Krzysztof M KM Kitel Radoslaw R Przetocka Sara S Golik Przemyslaw P Guzik Katarzyna K Musielak Bogdan B Dömling Alexander A Dubin Grzegorz G Holak Tad A TA
Structure (London, England : 1993) 20151022 12
Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has recently provided breakthrough progress in the treatment of melanoma, non-small cell lung cancer, and other types of cancer. Small-molecule drugs interfering with this pathway are highly awaited, but their development is hindered by insufficient structural information. This study reveals the molecular details of the human PD-1/PD-L1 interaction based on an X-ray structure of the complex. First, it is shown that the li ...[more]