Ontology highlight
ABSTRACT:
SUBMITTER: Morsut L
PROVIDER: S-EPMC4752866 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Morsut Leonardo L Roybal Kole T KT Xiong Xin X Gordley Russell M RM Coyle Scott M SM Thomson Matthew M Lim Wendell A WA
Cell 20160128 4
The Notch protein is one of the most mechanistically direct transmembrane receptors-the intracellular domain contains a transcriptional regulator that is released from the membrane when engagement of the cognate extracellular ligand induces intramembrane proteolysis. We find that chimeric forms of Notch, in which both the extracellular sensor module and the intracellular transcriptional module are replaced with heterologous protein domains, can serve as a general platform for generating novel ce ...[more]