Unknown

Dataset Information

0

Effect of vitamin D3 treatment on endothelial function in obese adolescents.


ABSTRACT: Obesity in children is associated with vitamin D deficiency and endothelial dysfunction. It is not known if treatment with vitamin D improves endothelial function in obese adolescents.This study aimed to determine whether treatment with vitamin D3 improves endothelial function in obese adolescents.Nineteen obese adolescents, 13-18 years of age, with 25-hydroxy vitamin D (25[OH]D) levels <75?nmol?L(-1) were treated with 100?000?IU vitamin D3 orally once a month for 3 months in an open-label, single-centre prospective trial. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery at study entry and 1 month after the third dose of vitamin D3 . Biochemical parameters, including calcium, fasting lipids, glucose, insulin and high-sensitivity C-reactive protein, were also obtained.Mean 25(OH)D levels increased from 55.9?±?12.2 to 86.9?±?16.7?nmol?L(-1) (P?

SUBMITTER: Javed A 

PROVIDER: S-EPMC4753130 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Effect of vitamin D3 treatment on endothelial function in obese adolescents.

Javed A A   Kullo I J IJ   Balagopal P Babu PB   Kumar S S  

Pediatric obesity 20150814 4


<h4>Background</h4>Obesity in children is associated with vitamin D deficiency and endothelial dysfunction. It is not known if treatment with vitamin D improves endothelial function in obese adolescents.<h4>Objective</h4>This study aimed to determine whether treatment with vitamin D3 improves endothelial function in obese adolescents.<h4>Methods</h4>Nineteen obese adolescents, 13-18 years of age, with 25-hydroxy vitamin D (25[OH]D) levels <75 nmol L(-1) were treated with 100 000 IU vitamin D3 or  ...[more]

Similar Datasets

| S-EPMC5992315 | biostudies-literature
| S-EPMC5435351 | biostudies-literature
| S-EPMC6567161 | biostudies-literature
| S-EPMC7138671 | biostudies-literature
| S-EPMC6446320 | biostudies-literature
| S-EPMC8287040 | biostudies-literature
| S-EPMC6406072 | biostudies-literature
| S-EPMC5735148 | biostudies-literature
| S-EPMC8564918 | biostudies-literature
| S-EPMC4846157 | biostudies-literature