Ontology highlight
ABSTRACT:
SUBMITTER: Colonna L
PROVIDER: S-EPMC4753131 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Colonna Lucrezia L Parry Graham C GC Panicker Sandip S Elkon Keith B KB
Clinical immunology (Orlando, Fla.) 20160106
Complement activation contributes to inflammation in many diseases, yet it also supports physiologic apoptotic cells (AC) clearance and its downstream immunosuppressive effects. The roles of individual complement components in AC phagocytosis have been difficult to dissect with artificially depleted sera. Using human in vitro systems and the novel antibody complement C1s inhibitor TNT003, we uncoupled the role of the enzymatic activation of the classical pathway from the opsonizing role of C1q i ...[more]