Sex-dependent and independent effects of long-term voluntary wheel running on Bdnf mRNA and protein expression.

ABSTRACT:

Unlabelled

The beneficial effects of physical activity on brain health (synaptogenesis, neurogenesis, enhanced synaptic plasticity, improved learning and memory) appear to be mediated through changes in region-specific expression of neurotrophins, transcription factors, and postsynaptic receptors, though investigations of sex differences in response to long-term voluntary wheel running are limited.

Purpose

To examine the effect of five months of voluntary wheel running on hippocampal mRNA and protein expression of factors critical for exercise-induced structural and functional plasticity in male and female adult mice.

Methods

At 8weeks of age, male and female C57BL/6 mice were individually housed with (PA; n=20; 10 male) or without (SED; n=20; 10 male) access to a com

SUBMITTER: Venezia AC 

PROVIDER: S-EPMC4753141 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature