Inverse relationship between a genetic risk score of 31 BMI loci and weight change before and after reaching middle age.

ABSTRACT:

Background/objective

Genome-wide-association studies have identified numerous body mass index (BMI)-associated variants, but it is unclear how these relate to weight gain in adults at different ages.

Methods

We examined the association of a genetic risk score (GRS), consisting of 31 BMI-associated variants, with an annual weight change (AWC) and a substantial weight gain (SWG) of 10% by comparing self-reported weight at 20 years (y) with baseline weight (mean: 58 y; s.d.: 8 y) in 21407 participants from the Malmö Diet and Cancer Study (MDCS), and comparing baseline weight to weight at follow-up (mean: 73 y; s.d.: 6 y) among 2673 participants. Association between GRS and AWG and SWG was replicated in 4327 GLACIER (Gene x Lifestyle interactions And Complex traits Involved in E

SUBMITTER: Rukh G 

PROVIDER: S-EPMC4753358 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature