Simulation shows that HLA-matched stem cell donors can remain unidentified in donor searches.

ABSTRACT: The heterogeneous nature of HLA information in real-life stem cell donor registries may hamper unrelated donor searches. It is even possible that fully HLA-matched donors with incomplete HLA information are not identified. In our simulation study, we estimated the probability of these unnecessarily failed donor searches. For that purpose, we carried out donor searches in several virtual donor registries. The registries differed by size, composition with respect to HLA typing levels, and genetic diversity. When up to three virtual HLA typing requests were allowed within donor searches, the share of unnecessarily failed donor searches ranged from 1.19% to 4.13%, thus indicating that non-identification of completely HLA-matched stem cell donors is a problem of practical relevance. The followi

SUBMITTER: Sauter J 

PROVIDER: S-EPMC4753406 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature