Meta-analysis of Positive and Negative Symptoms Reveals Schizophrenia Modifier Genes.

ABSTRACT:

Background

Evidence suggests that genetic factors may influence both schizophrenia (Scz) and its clinical presentation. In recent years, genome-wide association studies (GWAS) have demonstrated considerable success in identifying risk loci. Detection of "modifier loci" has the potential to further elucidate underlying disease processes.

Methods

We performed GWAS of empirically derived positive and negative symptom scales in Irish cases from multiply affected pedigrees and a larger, independent case-control sample, subsequently combining these into a large Irish meta-analysis. In addition to single-SNP associations, we considered gene-based and pathway analyses to better capture convergent genetic effects, and to facilitate biological interpretation of these findings. Replica

SUBMITTER: Edwards AC 

PROVIDER: S-EPMC4753595 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature