Ontology highlight
ABSTRACT:
SUBMITTER: South AP
PROVIDER: S-EPMC4753672 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
South Andrew P AP Purdie Karin J KJ Watt Stephen A SA Haldenby Sam S den Breems Nicoline N Dimon Michelle M Arron Sarah T ST Kluk Michael J MJ Aster Jon C JC McHugh Angela A Xue Dylan J DJ Dayal Jasbani Hs JH Robinson Kim S KS Rizvi Sm Hasan SH Proby Charlotte M CM Harwood Catherine A CA Leigh Irene M IM
The Journal of investigative dermatology 20140324 10
Cutaneous SCC (cSCC) is the most frequently occuring skin cancer with metastatic potential and can manifest rapidly as a common side effect in patients receiving systemic kinase inhibitors. Here, we use massively parallel exome and targeted level sequencing of 132 sporadic cSCCs and of 39 squamoproliferative lesions and cSCCs arising in patients receiving the BRAF inhibitor vemurafenib, as well as 10 normal skin samples, to identify NOTCH1 mutation as an early event in squamous cell carcinogenes ...[more]