Ontology highlight
ABSTRACT:
SUBMITTER: Leszczynska KB
PROVIDER: S-EPMC4753685 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Leszczynska Katarzyna B KB Göttgens Eva-Leonne EL Biasoli Deborah D Olcina Monica M MM Ient Jonathan J Anbalagan Selvakumar S Bernhardt Stephan S Giaccia Amato J AJ Hammond Ester M EM
Scientific reports 20160215
Hypoxia-induced replication stress is one of the most physiologically relevant signals known to activate ATM in tumors. Recently, the ATM interactor (ATMIN) was identified as critical for replication stress-induced activation of ATM in response to aphidicolin and hydroxyurea. This suggests an essential role for ATMIN in ATM regulation during hypoxia, which induces replication stress. However, ATMIN also has a role in base excision repair, a process that has been demonstrated to be repressed and ...[more]