Unknown

Dataset Information

0

Genome sequence of a 45,000-year-old modern human from western Siberia.


ABSTRACT: We present the high-quality genome sequence of a ?45,000-year-old modern human male from Siberia. This individual derives from a population that lived before-or simultaneously with-the separation of the populations in western and eastern Eurasia and carries a similar amount of Neanderthal ancestry as present-day Eurasians. However, the genomic segments of Neanderthal ancestry are substantially longer than those observed in present-day individuals, indicating that Neanderthal gene flow into the ancestors of this individual occurred 7,000-13,000 years before he lived. We estimate an autosomal mutation rate of 0.4 × 10(-9) to 0.6 × 10(-9) per site per year, a Y chromosomal mutation rate of 0.7 × 10(-9) to 0.9 × 10(-9) per site per year based on the additional substitutions that have occurred in present-day non-Africans compared to this genome, and a mitochondrial mutation rate of 1.8 × 10(-8) to 3.2 × 10(-8) per site per year based on the age of the bone.

SUBMITTER: Fu Q 

PROVIDER: S-EPMC4753769 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications


We present the high-quality genome sequence of a ∼45,000-year-old modern human male from Siberia. This individual derives from a population that lived before-or simultaneously with-the separation of the populations in western and eastern Eurasia and carries a similar amount of Neanderthal ancestry as present-day Eurasians. However, the genomic segments of Neanderthal ancestry are substantially longer than those observed in present-day individuals, indicating that Neanderthal gene flow into the a  ...[more]

Similar Datasets

| S-EPMC8175239 | biostudies-literature
| S-EPMC10805732 | biostudies-literature
| S-EPMC4131216 | biostudies-literature
| S-EPMC1963477 | biostudies-literature
| S-EPMC2373799 | biostudies-literature
| S-EPMC1891266 | biostudies-literature
| S-EPMC3367347 | biostudies-literature
| S-EPMC4557276 | biostudies-literature
| S-EPMC6684528 | biostudies-literature
| S-EPMC3291046 | biostudies-literature