Ontology highlight
ABSTRACT:
SUBMITTER: Johnston M
PROVIDER: S-EPMC4754036 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Johnston Michael M Blue Mary E ME Naidu Sakkubai S
F1000Research 20151222
Rett syndrome is an extremely disabling X-linked nervous system disorder that mainly affects girls in early childhood and causes autism-like behavior, severe intellectual disability, seizures, sleep disturbances, autonomic instability, and other disorders due to mutations in the MeCP2 (methyl CpG-binding protein 2) transcription factor. The disorder targets synapses and synaptic plasticity and has been shown to disrupt the balance between glutamate excitatory synapses and GABAergic inhibitory sy ...[more]