Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
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ABSTRACT:
SUBMITTER: Ceccarelli M
PROVIDER: S-EPMC4754110 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
Ceccarelli Michele M Barthel Floris P FP Malta Tathiane M TM Sabedot Thais S TS Salama Sofie R SR Murray Bradley A BA Morozova Olena O Newton Yulia Y Radenbaugh Amie A Pagnotta Stefano M SM Anjum Samreen S Wang Jiguang J Manyam Ganiraju G Zoppoli Pietro P Ling Shiyun S Rao Arjun A AA Grifford Mia M Cherniack Andrew D AD Zhang Hailei H Poisson Laila L Carlotti Carlos Gilberto CG Tirapelli Daniela Pretti da Cunha DP Rao Arvind A Mikkelsen Tom T Lau Ching C CC Yung W K Alfred WK Rabadan Raul R Huse Jason J Brat Daniel J DJ Lehman Norman L NL Barnholtz-Sloan Jill S JS Zheng Siyuan S Hess Kenneth K Rao Ganesh G Meyerson Matthew M Beroukhim Rameen R Cooper Lee L Akbani Rehan R Wrensch Margaret M Haussler David D Aldape Kenneth D KD Laird Peter W PW Gutmann David H DH Noushmehr Houtan H Iavarone Antonio A Verhaak Roel G W RG
Cell 20160101 3
Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas from The Cancer Genome Atlas and used molecular profiles to improve disease classification, identify molecular correlations, and provide insights into the progression from low- to high-grade disease. Whole-genome sequencing data analysis determined th ...[more]
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