Heat-Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET.

ABSTRACT: Heat-induced radiolabeling (HIR) yielded (89) Zr-Feraheme (FH) nanoparticles (NPs) that were used to determine NP pharmacokinetics (PK) by positron emission tomography (PET). Standard uptake values indicated a fast hepatic uptake that corresponded to blood clearance, and a second, slow uptake process by lymph nodes and spleen. By cytometry, NPs were internalized by circulating monocytes and monocytes in?vitro. Using an IV injection of HIR (89) Zr-FH (rather than in?vitro cell labeling), PET/PK provided a view of monocyte trafficking, a key component of the immune response.

SUBMITTER: Normandin MD 

PROVIDER: S-EPMC4754124 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature