Molecular mechanisms underlying RB protein function.
Ontology highlight
ABSTRACT:
SUBMITTER: Dick FA
PROVIDER: S-EPMC4754300 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Molecular mechanisms underlying RB protein function.
Dick Frederick A FA Rubin Seth M SM
Nature reviews. Molecular cell biology 20130418 5
Inactivation of the RB protein is one of the most fundamental events in cancer. Coming to a molecular understanding of its function in normal cells and how it impedes cancer development has been challenging. Historically, the ability of RB to regulate the cell cycle placed it in a central role in proliferative control, and research focused on RB regulation of the E2F family of transcription factors. Remarkably, several recent studies have found additional tumour-suppressor functions of RB, inclu ...[more]
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