Ontology highlight
ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC4754351 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Xu Zhen Z Takizawa Fumio F Parra David D Gómez Daniela D von Gersdorff Jørgensen Louise L LaPatra Scott E SE Sunyer J Oriol JO
Nature communications 20160212
Gas-exchange structures are critical for acquiring oxygen, but they also represent portals for pathogen entry. Local mucosal immunoglobulin responses against pathogens in specialized respiratory organs have only been described in tetrapods. Since fish gills are considered a mucosal surface, we hypothesized that a dedicated mucosal immunoglobulin response would be generated within its mucosa on microbial exposure. Supporting this hypothesis, here we demonstrate that following pathogen exposure, I ...[more]