Ontology highlight
ABSTRACT:
SUBMITTER: Lecaros RL
PROVIDER: S-EPMC4754546 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Molecular therapy : the journal of the American Society of Gene Therapy 20150916 1
Photodynamic therapy (PDT) is believed to promote hypoxic conditions to tumor cells leading to overexpression of angiogenic markers such as vascular endothelial growth factor (VEGF). In this study, PDT was combined with lipid-calcium-phosphate nanoparticles (LCP NPs) to deliver VEGF-A small interfering RNA (siVEGF-A) to human head and neck squamous cell carcinoma (HNSCC) xenograft models. VEGF-A were significantly decreased for groups treated with siVEGF-A in human oral squamous cancer cell (HOS ...[more]