Ontology highlight
ABSTRACT:
SUBMITTER: Liu K
PROVIDER: S-EPMC4754636 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Liu Ke K Lei Run R Li Qiong Q Wang Xin-Xin XX Wu Qian Q An Peng P Zhang Jianchao J Zhu Minyan M Xu Zhiheng Z Hong Yang Y Wang Fudi F Shen Ying Y Li Hongchang H Li Huashun H
Scientific reports 20160216
Transferrin receptor (TFR) is an important iron transporter regulating iron homeostasis and has long been used as a marker for clathrin mediated endocytosis. However, little is known about its additional function other than iron transport in the development of central nervous system (CNS). Here we demonstrate that TFR functions as a regulator to control AMPA receptor trafficking efficiency and synaptic plasticity. The conditional knockout (KO) of TFR in neural progenitor cells causes mice to dev ...[more]