Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.

ABSTRACT:

Objective

To determine if intravenous thiamine would reduce lactate in patients with septic shock.

Design

Randomized, double-blind, placebo-controlled trial.

Setting

Two US hospitals.

Patients

Adult patients with septic shock and elevated (> 3 mmol/L) lactate between 2010 and 2014.

Interventions

Thiamine 200 mg or matching placebo twice daily for 7 days or until hospital discharge.

Measurements and main results

The primary outcome was lactate levels 24 hours after the first study dose. Of 715 patients meeting the inclusion criteria, 88 patients were enrolled and received study drug. There was no difference in the primary outcome of lactate levels at 24 hours after study start between the thiamine and placebo groups (median: 2.5 mmol/L [1.5, 3.4] v

SUBMITTER: Donnino MW 

PROVIDER: S-EPMC4754670 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature