Ontology highlight
ABSTRACT:
SUBMITTER: Rondelli V
PROVIDER: S-EPMC4754687 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Rondelli Valeria V Brocca Paola P Motta Simona S Messa Massimo M Colombo Laura L Salmona Mario M Fragneto Giovanna G Cantù Laura L Del Favero Elena E
Scientific reports 20160216
The role of first-stage β-amyloid aggregation in the development of the Alzheimer disease, is widely accepted but still unclear. Intimate interaction with the cell membrane is invoked. We designed Neutron Reflectometry experiments to reveal the existence and extent of the interaction between β-amyloid (Aβ) peptides and a lone customized biomimetic membrane, and their dependence on the aggregation state of the peptide. The membrane, asymmetrically containing phospholipids, GM1 and cholesterol in ...[more]