Ontology highlight
ABSTRACT:
SUBMITTER: Aparicio T
PROVIDER: S-EPMC4754713 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
The Journal of cell biology 20160201 4
Repair of DNA double-strand breaks (DSBs) with complex ends poses a special challenge, as additional processing is required before DNA ligation. For example, protein-DNA adducts must be removed to allow repair by either nonhomologous end joining or homology-directed repair. Here, we investigated the processing of topoisomerase II (Top2)-DNA adducts induced by treatment with the chemotherapeutic agent etoposide. Through biochemical analysis in Xenopus laevis egg extracts, we establish that the MR ...[more]