Ontology highlight
ABSTRACT:
SUBMITTER: Matos CA
PROVIDER: S-EPMC4754714 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Matos Carlos A CA Nóbrega Clévio C Louros Susana R SR Almeida Bruno B Ferreiro Elisabete E Valero Jorge J Pereira de Almeida Luís L Macedo-Ribeiro Sandra S Carvalho Ana Luísa AL
The Journal of cell biology 20160201 4
Different neurodegenerative diseases are caused by aberrant elongation of repeated glutamine sequences normally found in particular human proteins. Although the proteins involved are ubiquitously distributed in human tissues, toxicity targets only defined neuronal populations. Changes caused by an expanded polyglutamine protein are possibly influenced by endogenous cellular mechanisms, which may be harnessed to produce neuroprotection. Here, we show that ataxin-3, the protein involved in spinoce ...[more]