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Low c-Met expression levels are prognostic for and predict the benefits of temozolomide chemotherapy in malignant gliomas.

ABSTRACT: Aberrant c-Met has been implicated in the development of many cancers. The objective of this study was to identify an unfavorable prognostic marker that might guide decisions regarding clinical treatment strategies for high-grade gliomas. C-Met expression was measured using immunohistochemistry in 783 gliomas, and we further analyzed c-Met mRNA levels using the Agilent Whole Genome mRNA Microarray in 286 frozen samples. In vitro, we performed cell migration and invasion assays. Cell sensitivity to temozolomide (TMZ) chemotherapy was determined using MTT assays. Both mRNA and protein levels of c-Met were significantly associated with tumor grade progression and inversely correlated with overall and progression-free survival in high-grade gliomas (all P?

SUBMITTER: Li MY

PROVIDER: S-EPMC4754763 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Low c-Met expression levels are prognostic for and predict the benefits of temozolomide chemotherapy in malignant gliomas.

Li Ming-Yang MY Yang Pei P Liu Yan-Wei YW Zhang Chuan-Bao CB Wang Kuan-Yu KY Wang Yin-Yan YY Yao Kun K Zhang Wei W Qiu Xiao-Guang XG Li Wen-Bin WB Peng Xiao-Xia XX Wang Yong-Zhi YZ Jiang Tao T

Scientific reports 20160216

Aberrant c-Met has been implicated in the development of many cancers. The objective of this study was to identify an unfavorable prognostic marker that might guide decisions regarding clinical treatment strategies for high-grade gliomas. C-Met expression was measured using immunohistochemistry in 783 gliomas, and we further analyzed c-Met mRNA levels using the Agilent Whole Genome mRNA Microarray in 286 frozen samples. In vitro, we performed cell migration and invasion assays. Cell sensitivity ...[more]

PMID: 26879272

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