Weight loss and progressive left ventricular remodelling: The Multi-Ethnic Study of Atherosclerosis (MESA).

ABSTRACT:

Aims

Impact of weight loss on cardiac structure has not been extensively investigated in large, multi-ethnic, community-based populations. We investigated the longitudinal impact of weight loss on cardiac structure by cardiac magnetic resonance (CMR).

Methods and results

2351 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent CMR at Exam 1 (2002) and Exam 5 (2011) were included. Primary outcomes were percentage change in LV mass (indexed to height) and LV mass-to-volume ratio (concentric LV remodelling). Multivariable linear regression was used to measure the association between outcomes and weight change. At median 9.4 years' follow-up, 639 individuals (27%) experienced >5% weight loss (median 6.9 kg) and 511 (22%) had >5% weight gain (median 6.4

SUBMITTER: Shah RV 

PROVIDER: S-EPMC4754791 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature