Ontology highlight
ABSTRACT:
SUBMITTER: Ciferri C
PROVIDER: S-EPMC4754795 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Cell 20080501 3
Kinetochores are proteinaceous assemblies that mediate the interaction of chromosomes with the mitotic spindle. The 180 kDa Ndc80 complex is a direct point of contact between kinetochores and microtubules. Its four subunits contain coiled coils and form an elongated rod structure with functional globular domains at either end. We crystallized an engineered "bonsai" Ndc80 complex containing a shortened rod domain but retaining the globular domains required for kinetochore localization and microtu ...[more]