Ontology highlight
ABSTRACT:
SUBMITTER: Ciferri C
PROVIDER: S-EPMC4754795 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Ciferri Claudio C Pasqualato Sebastiano S Screpanti Emanuela E Varetti Gianluca G Santaguida Stefano S Dos Reis Gabriel G Maiolica Alessio A Polka Jessica J De Luca Jennifer G JG De Wulf Peter P Salek Mogjiborahman M Rappsilber Juri J Moores Carolyn A CA Salmon Edward D ED Musacchio Andrea A
Cell 20080501 3
Kinetochores are proteinaceous assemblies that mediate the interaction of chromosomes with the mitotic spindle. The 180 kDa Ndc80 complex is a direct point of contact between kinetochores and microtubules. Its four subunits contain coiled coils and form an elongated rod structure with functional globular domains at either end. We crystallized an engineered "bonsai" Ndc80 complex containing a shortened rod domain but retaining the globular domains required for kinetochore localization and microtu ...[more]