Expression and promotor hypermethylation of miR-34a in the various histological subtypes of ovarian cancer.

ABSTRACT:

Background

An increasing body of evidence shows that miR-34 family has tumor suppressive properties mediating apoptosis, cell cycle arrest and senescence. In ovarian cancer, miR34 family members were found to be under expressed. Particularly miR-34a has been revealed to be a direct transcriptional target of p53 which is frequently mutated in epithelial ovarian carcinomas especially in high grade serous cancer. Moreover, methylation of miR-34a CpG Islands was found to down-regulate miR-34a expression. The aim of this study was to investigate the clinical relevance of mir34a as well as its promoter methylation in a subset of 133 ovarian cancers with a special focus on the p53 mutation status, the dualistic type I and type II ovarian cancer model and the different histotypes.

Metho

SUBMITTER: Schmid G 

PROVIDER: S-EPMC4754861 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature