Task-related default mode network modulation and inhibitory control in ADHD: effects of motivation and methylphenidate.

ABSTRACT:

Background

Deficits characteristic of attention deficit/hyperactivity disorder (ADHD), including poor attention and inhibitory control, are at least partially alleviated by factors that increase engagement of attention, suggesting a hypodopaminergic reward deficit. Lapses of attention are associated with attenuated deactivation of the default mode network (DMN), a distributed brain system normally deactivated during tasks requiring attention to the external world. Task-related DMN deactivation has been shown to be attenuated in ADHD relative to controls. We hypothesised that motivational incentives to balance speed against restraint would increase task engagement during an inhibitory control task, enhancing DMN deactivation in ADHD. We also hypothesised that methylphenidate, an ind

SUBMITTER: Liddle EB 

PROVIDER: S-EPMC4754961 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature