HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I.
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ABSTRACT:
SUBMITTER: Choi SJ
PROVIDER: S-EPMC4755110 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I.
Choi Su Jin SJ Lee Hyun-Cheol HC Kim Jae-Hoon JH Park Song Yi SY Kim Tae-Hwan TH Lee Woon-Kyu WK Jang Duk-Jae DJ Yoon Ji-Eun JE Choi Young-Il YI Kim Seihwan S Ma JinYeul J Kim Chul-Joong CJ Yao Tso-Pang TP Jung Jae U JU Lee Joo-Yong JY Lee Jong-Soo JS
The EMBO journal 20160108 4
RIG-I is a key cytosolic sensor that detects RNA viruses through its C-terminal region and activates the production of antiviral interferons (IFNs) and proinflammatory cytokines. While posttranslational modification has been demonstrated to regulate RIG-I signaling activity, its significance for the sensing of viral RNAs remains unclear. Here, we first show that the RIG-I C-terminal region undergoes deacetylation to regulate its viral RNA-sensing activity and that the HDAC6-mediated deacetylatio ...[more]
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