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Mouse models of colorectal cancer as preclinical models.

ABSTRACT: In this review, we discuss the application of mouse models to the identification and pre-clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early disease biomarkers. Large-scale genomic, transcriptomic and epigenomic profiling of colorectal carcinomas has led to the identification of many candidate genes whose direct contribution to tumourigenesis is yet to be defined; we discuss the utility of cross-species comparative 'omics-based approaches to this problem. We highlight recent progress in modelling late-stage disease using mice, and discuss ways in which mouse models could better recapitulate the complexity of human cancers to tackle the problem of therapeutic resistance and recurrence after surgical resection.

SUBMITTER: McIntyre RE

PROVIDER: S-EPMC4755199 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Mouse models of colorectal cancer as preclinical models.

McIntyre Rebecca E RE Buczacki Simon J A SJ Arends Mark J MJ Adams David J DJ

BioEssays : news and reviews in molecular, cellular and developmental biology 20150626 8

In this review, we discuss the application of mouse models to the identification and pre-clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early disease biomarkers. Large-scale genomic, transcriptomic and epigenomic profiling of colorectal carcinomas has led to the identification of many candidate genes whose direct contribution to tumourigenesis is yet to be defined; we discuss the utility of cross-species comparative 'omics-based approaches to this pr ...[more]

PMID: 26115037

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