Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin.
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ABSTRACT:
SUBMITTER: Futai K
PROVIDER: S-EPMC4755312 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Publications
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin.
Futai Kensuke K Kim Myung Jong MJ Hashikawa Tsutomu T Scheiffele Peter P Sheng Morgan M Hayashi Yasunori Y
Nature neuroscience 20070121 2
The structure and function of presynaptic and postsynaptic components of the synapse are highly coordinated. How such coordination is achieved and the molecules involved in this process have not been clarified. Several lines of evidence suggest that presynaptic functionalities are regulated by retrograde mechanisms from the postsynaptic side. We therefore sought postsynaptic mechanisms responsible for trans-synaptic regulation of presynaptic function at excitatory synapses in rat hippocampal CA1 ...[more]
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