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Management of multidrug-resistant TB: novel treatments and their expansion to low resource settings.

ABSTRACT: Despite overall progress in global TB control, the rising burden of multidrug-resistant TB (MDR-TB) threatens to undermine efforts to end the worldwide epidemic. Of the 27 countries classified as high burden for MDR-TB, 17 are in 'low' or 'low-middle' income countries. Shorter, all oral and less toxic multidrug combinations are required to improve treatment outcomes in these settings. Suitability for safe co-administration with HIV drugs is also desirable. A range of strategies and several new drugs (including bedaquiline, delamanid and linezolid) are currently undergoing advanced clinical evaluations to define their roles in achieving these aims. However, several clinical questions and logistical challenges need to be overcome before these new MDR-TB treatments fulfil their potential.

SUBMITTER: Sloan DJ

PROVIDER: S-EPMC4755422 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Management of multidrug-resistant TB: novel treatments and their expansion to low resource settings.

Sloan Derek J DJ Lewis Joseph M JM

Transactions of the Royal Society of Tropical Medicine and Hygiene 20160301 3

Despite overall progress in global TB control, the rising burden of multidrug-resistant TB (MDR-TB) threatens to undermine efforts to end the worldwide epidemic. Of the 27 countries classified as high burden for MDR-TB, 17 are in 'low' or 'low-middle' income countries. Shorter, all oral and less toxic multidrug combinations are required to improve treatment outcomes in these settings. Suitability for safe co-administration with HIV drugs is also desirable. A range of strategies and several new d ...[more]

PMID: 26884496

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Dataset Information

Management of multidrug-resistant TB: novel treatments and their expansion to low resource settings.

Publications

Management of multidrug-resistant TB: novel treatments and their expansion to low resource settings.

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