Genetic polymorphisms of CASR and cancer risk: evidence from meta-analysis and HuGE review.

ABSTRACT:

Background

CASR gene appears to be involved in cancer biology and physiology. However, a number of studies investigating CASR polymorphisms and cancer risks have presented inconclusive results. Thus, a systematic review and a meta-analysis of the effect of CASR polymorphisms on several cancer risks were performed to suggest a statistical evidence for the association of CASR polymorphisms with cancer risks.

Methods

MEDLINE, EMBASE, Web of Science, Scopus, and the HuGE databases were searched. Nineteen articles of case-control and cohort studies were included for the final analysis.

Results

The colorectal cancer risk was reduced in proximal (odds ratio [OR] =0.679, P=0.001) and distal (OR =0.753, P=0.026) colon sites with GG genotype of CASR rs1042636 and increased in d

SUBMITTER: Jeong S 

PROVIDER: S-EPMC4755434 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature