The Cytolytic Amphipathic ?(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma.
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ABSTRACT:
SUBMITTER: Eike LM
PROVIDER: S-EPMC4755540 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
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The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma.
Eike Liv-Marie LM Mauseth Brynjar B Camilio Ketil André KA Rekdal Øystein Ø Sveinbjørnsson Baldur B
PloS one 20160216 2
In the present study we examined the ability of the amino acid derivative LTX-401 to induce cell death in cancer cell lines, as well as the capacity to induce regression in a murine melanoma model. Mode of action studies in vitro revealed lytic cell death and release of danger-associated molecular pattern molecules, preceded by massive cytoplasmic vacuolization and compromised lysosomes in treated cells. The use of a murine melanoma model demonstrated that the majority of animals treated with in ...[more]
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