Effect of Serum Cholesterol on Insulin Secretory Capacity: Shimane CoHRE Study.

ABSTRACT:

Objectives

Previous studies indicate that, in addition to the blood glucose level, the lipid level in the blood may affect functions of pancreatic beta cells. In this study, we aimed to examine whether there was a relationship between the serum level of total cholesterol (TC) and the insulin secretory capacity in healthy subjects.

Subjects and methods

In participants of health examinations conducted from 2006 to 2010, we analyzed data from a total of 2,499 subjects (1,057 men and 1,442 women) after exclusion of individuals with dyslipidemia, thyroid dysfunction, diabetes, HbA1c≥6.5%, or fasting blood glucose≥126 mg/dL. Homeostasis model assessment for beta cell function (HOMA-beta) was utilized as a model representing the pancreatic beta cell function.

Results

Althoug

SUBMITTER: Wada M 

PROVIDER: S-EPMC4755542 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature