Ontology highlight
ABSTRACT:
SUBMITTER: Kumar K
PROVIDER: S-EPMC4755915 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Kumar Krishan K Chow Christina R CR Ebine Kazumi K Arslan Ahmet D AD Kwok Benjamin B Bentrem David J DJ Eckerdt Frank D FD Platanias Leonidas C LC Munshi Hidayatullah G HG
Molecular cancer research : MCR 20151125 2
<h4>Unlabelled</h4>Human pancreatic ductal adenocarcinoma (PDAC) tumors are associated with dysregulation of mRNA translation. In this report, it is demonstrated that PDAC cells grown in collagen exhibit increased activation of the MAPK-interacting protein kinases (MNK) that mediate eIF4E phosphorylation. Pharmacologic and genetic targeting of MNKs reverse epithelial-mesenchymal transition (EMT), decrease cell migration, and reduce protein expression of the EMT-regulator ZEB1 without affecting Z ...[more]