Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers.

ABSTRACT: The exposure-response for hexavalent chromium (Cr(VI))-induced lung cancer among workers of the Painesville Ohio chromate production facility has been used internationally for quantitative risk assessment of environmental and occupational exposures to airborne Cr(VI). We updated the mortality of 714 Painesville workers (including 198 short-term workers) through December 2011, reconstructed exposures, and conducted exposure-response modeling using Poisson and Cox regressions to provide quantitative lung cancer risk estimates. The average length of follow-up was 34.4 years with 24,535 person-years at risk. Lung cancer was significantly increased for the cohort (standardized mortality ratio (SMR)=186; 95% confidence interval (CI) 145-228), for those hired before 1959, those with >30-year tenu

SUBMITTER: Proctor DM 

PROVIDER: S-EPMC4756268 | biostudies-literature | 2016 Mar-Apr

REPOSITORIES: biostudies-literature