Ontology highlight
ABSTRACT:
SUBMITTER: Nocadello S
PROVIDER: S-EPMC4756620 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Nocadello S S Minasov G G Shuvalova L L Dubrovska I I Sabini E E Bagnoli F F Grandi G G Anderson W F WF
Acta crystallographica. Section D, Structural biology 20160101 Pt 1
Staphylococcal leukotoxins are a family of β-barrel, bicomponent, pore-forming toxins with membrane-damaging functions. These bacterial exotoxins share sequence and structural homology and target several host-cell types. Leukotoxin ED (LukED) is one of these bicomponent pore-forming toxins that Staphylococcus aureus produces in order to suppress the ability of the host to contain the infection. The recent delineation of the important role that LukED plays in S. aureus pathogenesis and the identi ...[more]