Ontology highlight
ABSTRACT:
SUBMITTER: Pilling LC
PROVIDER: S-EPMC4757025 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Pilling L C LC Joehanes R R Kacprowski T T Peters M M Jansen R R Karasik D D Kiel D P DP Harries L W LW Teumer A A Powell J J Levy D D Lin H H Lunetta K K Munson P P Bandinelli S S Henley W W Hernandez D D Singleton A A Tanaka T T van Grootheest G G Hofman A A Uitterlinden A G AG Biffar R R Gläser S S Homuth G G Malsch C C Völker U U Penninx B B van Meurs J B J JB Ferrucci L L Kocher T T Murabito J J Melzer D D
Physiological genomics 20151020 1
Lower muscle strength in midlife predicts disability and mortality in later life. Blood-borne factors, including growth differentiation factor 11 (GDF11), have been linked to muscle regeneration in animal models. We aimed to identify gene transcripts associated with muscle strength in adults. Meta-analysis of whole blood gene expression (overall 17,534 unique genes measured by microarray) and hand-grip strength in four independent cohorts (n = 7,781, ages: 20-104 yr, weighted mean = 56), adjuste ...[more]