Ontology highlight
ABSTRACT:
SUBMITTER: Fiorillo AA
PROVIDER: S-EPMC4757433 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Fiorillo Alyson A AA Heier Christopher R CR Novak James S JS Tully Christopher B CB Brown Kristy J KJ Uaesoontrachoon Kitipong K Vila Maria C MC Ngheim Peter P PP Bello Luca L Kornegay Joe N JN Angelini Corrado C Partridge Terence A TA Nagaraju Kanneboyina K Hoffman Eric P EP
Cell reports 20150828 10
The amount and distribution of dystrophin protein in myofibers and muscle is highly variable in Becker muscular dystrophy and in exon-skipping trials for Duchenne muscular dystrophy. Here, we investigate a molecular basis for this variability. In muscle from Becker patients sharing the same exon 45-47 in-frame deletion, dystrophin levels negatively correlate with microRNAs predicted to target dystrophin. Seven microRNAs inhibit dystrophin expression in vitro, and three are validated in vivo (miR ...[more]