Intraoperative intravital microscopy permits the study of human tumour vessels.
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ABSTRACT:
SUBMITTER: Fisher DT
PROVIDER: S-EPMC4757793 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
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Intraoperative intravital microscopy permits the study of human tumour vessels.
Fisher Daniel T DT Muhitch Jason B JB Kim Minhyung M Doyen Kurt C KC Bogner Paul N PN Evans Sharon S SS Skitzki Joseph J JJ
Nature communications 20160217
Tumour vessels have been studied extensively as they are critical sites for drug delivery, anti-angiogenic therapies and immunotherapy. As a preclinical tool, intravital microscopy (IVM) allows for in vivo real-time direct observation of vessels at the cellular level. However, to date there are no reports of intravital high-resolution imaging of human tumours in the clinical setting. Here we report the feasibility of IVM examinations of human malignant disease with an emphasis on tumour vasculat ...[more]
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