Altered endosome biogenesis in prostate cancer has biomarker potential.

ABSTRACT:

Unlabelled

Prostate cancer is the second most common form of cancer in males, affecting one in eight men by the time they reach the age of 70 years. Current diagnostic tests for prostate cancer have significant problems with both false negatives and false positives, necessitating the search for new molecular markers. A recent investigation of endosomal and lysosomal proteins revealed that the critical process of endosomal biogenesis might be altered in prostate cancer. Here, a panel of endosomal markers was evaluated in prostate cancer and nonmalignant cells and a significant increase in gene and protein expression was found for early, but not late endosomal proteins. There was also a differential distribution of early endosomes, and altered endosomal traffic and signaling of the t

SUBMITTER: Johnson IR 

PROVIDER: S-EPMC4757910 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature