Vaccination and all-cause child mortality from 1985 to 2011: global evidence from the Demographic and Health Surveys.

ABSTRACT: Based on models with calibrated parameters for infection, case fatality rates, and vaccine efficacy, basic childhood vaccinations have been estimated to be highly cost effective. We estimated the association of vaccination with mortality directly from survey data. Using 149 cross-sectional Demographic and Health Surveys, we determined the relationship between vaccination coverage and the probability of dying between birth and 5 years of age at the survey cluster level. Our data included approximately 1 million children in 68,490 clusters from 62 countries. We considered the childhood measles, bacillus Calmette-Guérin, diphtheria-pertussis-tetanus, polio, and maternal tetanus vaccinations. Using modified Poisson regression to estimate the relative risk of child mortality in each cluster, we

SUBMITTER: McGovern ME 

PROVIDER: S-EPMC4757942 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature