Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.

ABSTRACT: Biological diversity among mammals is remarkable. Mammalian body weights range seven orders of magnitude and lifespans differ more than 100-fold among species. While genetic, dietary, and pharmacological interventions can be used to modulate these traits in model organisms, it is unknown how they are determined by natural selection. By profiling metabolites in brain, heart, kidney, and liver tissues of 26 mammalian species representing ten taxonomical orders, we report metabolite patterns characteristic of organs, lineages, and species longevity. Our data suggest different rates of metabolite divergence across organs and reveal patterns representing organ-specific functions and lineage-specific physiologies. We identified metabolites that correlated with species lifespan, some of which wer

SUBMITTER: Ma S 

PROVIDER: S-EPMC4758382 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature