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Perceptions of family history and genetic testing and feasibility of pedigree development among African Americans with hypertension.

ABSTRACT: Pedigree development, family history, and genetic testing are thought to be useful in improving outcomes of chronic illnesses such as hypertension (HTN). However, the clinical utility of pedigree development is still unknown. Further, little is known about the perceptions of African Americans (AAs) of family history and genetic testing.This study examined the feasibility of developing pedigrees for AAs with HTN and explored perceptions of family history and genetic research among AAs with HTN.The US Surgeon General's My Family Health Portrait was administered, and 30-60 min in-person individual interviews were conducted. Descriptive statistics were used to analyze pedigree data. Interview transcripts were analyzed with content analysis and constant comparison.Twenty-nine AAs with HTN were recruited from one free clinic (15 women, 14 men; mean age 49 years, standard deviation (SD) 9.6). Twenty-six (90%) reported their family history in sufficient detail to develop a pedigree. Perceptions of family history included knowledge of HTN in the family, culturally influenced family teaching about HTN, and response to family history of HTN. Most participants agreed to future genetic testing and DNA collection because they wanted to help others; some said they needed more information and others expressed a concern for privacy.The majority of AAs in this sample possessed extensive knowledge of HTN within their family and were able to develop a three-generation pedigree with assistance. The majority were willing to participate in future genetic research.

SUBMITTER: Pettey CM

PROVIDER: S-EPMC4758451 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Perceptions of family history and genetic testing and feasibility of pedigree development among African Americans with hypertension.

Pettey Christina M CM McSweeney Jean C JC Stewart Katharine E KE Price Elvin T ET Cleves Mario A MA Heo Seongkum S Souder Elaine E

European journal of cardiovascular nursing 20141016 1

<h4>Background</h4>Pedigree development, family history, and genetic testing are thought to be useful in improving outcomes of chronic illnesses such as hypertension (HTN). However, the clinical utility of pedigree development is still unknown. Further, little is known about the perceptions of African Americans (AAs) of family history and genetic testing.<h4>Aims</h4>This study examined the feasibility of developing pedigrees for AAs with HTN and explored perceptions of family history and geneti ...[more]

PMID: 25322748

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Project description:ObjectivesIt is unclear whether family medical history influences the willingness to undergo genetic testing. This study aimed to determine how family history affected the willingness to undergo genetic testing for salt-sensitive hypertension in patients with and without hypertension.DesignCross-sectional study using a self-administered questionnaire.SettingSix primary care clinics and hospitals in Japan.ParticipantsConsecutive 1705 outpatients aged >20 years, 578 of whom had hypertension.Primary and secondary outcome measuresThe primary outcome variable was the willingness to undergo genetic testing to determine the risk of salt-sensitive hypertension, and the secondary variables were age, sex, education level, family history and concerns about hypertension. Factors associated with a willingness to undergo genetic testing were evaluated in patients with and without hypertension using a logistic regression model.ResultsIn the hypertension and non-hypertension groups, 323 (55.9%) and 509 patients (45.2%), respectively, were willing to undergo genetic testing. This willingness was related with a high level of education (adjusted OR (ad-OR): 1.81, 95% CI 1.12 to 2.93), family history of stroke (1.55, 1.04 to 2.31) and concerns about hypertension (2.04, 1.27 to 3.28) in the hypertension group, whereas in the non-hypertension group, it was influenced by education level (ad-OR: 1.45, 95% CI 1.13 to 1.86), family history of hypertension (1.52, 1.17 to 1.98) and concerns about hypertension (2.03, 1.53 to 2.68).ConclusionsThe influence of family history on the willingness to undergo genetic testing for risk of salt-sensitivity hypertension differed between participants with and without hypertension. In particular, participants without hypertension wished to know their likelihood of developing hypertension, whereas those with hypertension were interested to know the risk of stroke (a complication of hypertension). Family history could help better counsel patients about genetic testing on the basis of their medical history.

Dataset Information

Perceptions of family history and genetic testing and feasibility of pedigree development among African Americans with hypertension.

Publications

Perceptions of family history and genetic testing and feasibility of pedigree development among African Americans with hypertension.

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